Dr. Jose Mireles, a small-town physician known as "El Doctor," leads a civilian uprising in the Mexican state of Michoacán against the Knights Templar, a vicious drug gang that has caused havoc on the region for years. In Arizona's Altar Valley, a 52-mile-long desert stretch known as Cocaine Alley, Tim "Nailer" Foley, an American veteran, is in charge of a small paramilitary force called Arizona Border Recon, whose mission is to prevent Mexico's drug battles from spilling over our border.